abstract：:It has been appreciated for almost 20 years that members of the Chlamydiales possess a virulence-associated type III secretion mechanism. Given the obligate intracellular nature of these bacteria, defining exactly how type III secretion functions to promote pathogenesis has been challenging. We present a working model...

journal_title：Microbes and infection

authors： Ferrell JC,Fields KA

更新日期：2016-02-01 00:00:00

abstract：:Neisseria meningitidis is an opportunistic human pathogen that usually colonizes the nasopharyngeal mucosa asymptomatically. Upon invasion into the blood and central nervous system, this bacterium triggers a fulminant inflammatory reaction with the manifestations of septicemia and meningitis, causing high morbidity an...

journal_title：Microbes and infection

authors： Liu Y,Zhang D,Engström Å,Merényi G,Hagner M,Yang H,Kuwae A,Wan Y,Sjölinder M,Sjölinder H

更新日期：2016-02-01 00:00:00

abstract：:Currently, there is no specific antiviral therapy for HPV infection. We conducted a randomized open-label clinical trial of JB01-BD, an anti-HPV biological dressing from Shanxi Jinbo Pharmaceutical Co., Ltd., China, for treatment of HPV infection. Seventy-seven women with cervical infection by high-risk HPV were rando...

journal_title：Microbes and infection

authors： Guo X,Qiu L,Wang Y,Wang Y,Wang Q,Song L,Li Y,Huang K,Du X,Fan W,Jiang S,Wang Q,Li H,Yang Y,Meng Y,Zhu Y,Lu L,Jiang S

更新日期：2016-02-01 00:00:00

abstract：:Parachlamydia acanthamoebae is an obligate intracellular bacterium naturally infecting free-living amoebae. The role of this bacterium as an agent of pneumonia is suggested by sero-epidemiological studies and molecular surveys. Furthermore, P. acanthamoebae may escape macrophages microbicidal effectors. Recently, we d...

journal_title：Microbes and infection

authors： Pilloux L,Casson N,Sommer K,Klos A,Stehle JC,Pusztaszeri M,Greub G

更新日期：2015-11-01 00:00:00

abstract：:Genome sequences of 36 Rickettsia and Orientia were analyzed using Formal Order Analysis (FOA). This approach takes into account arrangement of nucleotides in each sequence. A numerical characteristic, the average distance (remoteness) - "g" was used to compare of genomes. Our results corroborated previous separation ...

journal_title：Microbes and infection

authors： Shpynov S,Pozdnichenko N,Gumenuk A

更新日期：2015-11-01 00:00:00

abstract：:A non-toxigenic tox gene-bearing (NTTB) Corynebacterium ulcerans was grown from the wound of a 61-year-old gardener and in a nasal specimen from the patient's asymptomatic dog. The two isolates were similar in terms of antibiogram, multilocus sequence typing (ST341), virulence genes, and only three SNPs were found to ...

journal_title：Microbes and infection

authors： Fuursted K,Søes LM,Crewe BT,Stegger M,Andersen PS,Christensen JJ

更新日期：2015-10-01 00:00:00

abstract：:Purging HIV-1 to cure the infection in patients undergoing suppressive antiretroviral therapy requires targeting all possible viral reservoirs. Other than the memory CD4(+) T cells, several other HIV-1 reservoirs have been identified. HIV-1 infection in the brain as a reservoir is well documented, but not fully charac...

journal_title：Microbes and infection

authors： Chauhan A

更新日期：2015-09-01 00:00:00

abstract：:The role of virus-derived small RNAs (vsRNAs) has been identified as an antiviral mechanism in plants, arthropods, and nematodes. Although mammalian DNA viruses have been observed to encode functional miRNAs, whether RNA virus infection generates functional vsRNAs remains under discussion. This article reviews the mos...

journal_title：Microbes and infection

authors： Weng KF,Hsieh PT,Huang HI,Shih SR

更新日期：2015-08-01 00:00:00

abstract：:Filifactor alocis, a previously unrecognized Gram-positive anaerobic rod, is now considered a new emerging pathogen that may play a significant role in periodontal disease. F. alocis' unique characteristics and variations at the molecular level that may be responsible for the functional changes required to mediate the...

journal_title：Microbes and infection

authors： Aruni AW,Mishra A,Dou Y,Chioma O,Hamilton BN,Fletcher HM

更新日期：2015-07-01 00:00:00

abstract：:Staphylococcus aureus is a major cause of hospital-acquired infections. The ability to survive on abiotic surfaces is an important characteristic that facilitates transmission between human hosts. We found that S. aureus survivors of dry surface incubation are resistant to subsequent dry stress exposure. Survivors als...

journal_title：Microbes and infection

authors： Maudsdotter L,Imai S,Ohniwa RL,Saito S,Morikawa K

更新日期：2015-06-01 00:00:00

abstract：:Evaluation of vector control is crucial for improving malaria containment and, according to World Health Organization, new complementary indicators would be very valuable. In this study the IgG response to the Anopheles-specific cE5 salivary protein was tested as a tool to evaluate the efficacy of insecticide-treated ...

journal_title：Microbes and infection

authors： Marie A,Ronca R,Poinsignon A,Lombardo F,Drame PM,Cornelie S,Besnard P,Le Mire J,Fiorentino G,Fortes F,Carnevale P,Remoue F,Arcà B

更新日期：2015-06-01 00:00:00

abstract：:CCR5-tropic (R5) immunodeficiency virus type 1 (HIV-1) strains are highly transmissible during the early stage of infection in humans, whereas CXCR4-tropic (X4) strains are less transmissible. This study aimed to explore the basis for early phase R5 and X4 HIV-1 infection in vivo by using humanized mice dually challen...

journal_title：Microbes and infection

authors： Terahara K,Ishige M,Ikeno S,Okada S,Kobayashi-Ishihara M,Ato M,Tsunetsugu-Yokota Y

更新日期：2015-05-01 00:00:00

abstract：:Autoantibodies against various components of host are known to occur in leprosy. Nerve damage is the primary cause of disability associated with leprosy. The aim of this study was to detect the level of autoantibodies and lympho-proliferative response against myelin basic protein (MBP) in leprosy patients (LPs) and th...

journal_title：Microbes and infection

authors： Singh I,Yadav AR,Mohanty KK,Katoch K,Sharma P,Mishra B,Bisht D,Gupta UD,Sengupta U

更新日期：2015-04-01 00:00:00

abstract：:Ebolavirus can cause a highly fatal and panic-generating human disease which may jump from bats to other mammals and human. High viral loads in body fluids allow efficient transmission by contact. Lack of effective antivirals, vaccines and public health infrastructures in parts of Africa make it difficult to health wo...

journal_title：Microbes and infection

authors： To KK,Chan JF,Tsang AK,Cheng VC,Yuen KY

更新日期：2015-02-01 00:00:00

abstract：:In developed countries, enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a leading cause of bloody diarrhea and renal failures in human. Understanding strategies employed by EHEC to colonize the intestine is of major importance since to date no cure exists to eradicate the pathogen. In this study, the adaptive res...

journal_title：Microbes and infection

authors： Le Bihan G,Jubelin G,Garneau P,Bernalier-Donadille A,Martin C,Beaudry F,Harel J

更新日期：2015-01-01 00:00:00

abstract：:Pathogenic Leptospira species are the causative agents of leptospirosis, a global zoonotic infectious disease. Toxin-antitoxin (TA) modules have been confirmed as stress-response elements that induce prokaryotic and eukaryotic cell-growth arrest or death, but their role in the virulence of Leptospira has not been repo...

journal_title：Microbes and infection

authors： Komi KK,Ge YM,Xin XY,Ojcius DM,Sun D,Hu WL,Zhao X,Lin X,Yan J

更新日期：2015-01-01 00:00:00

abstract：:This article explores one of a citation classics in medical literature-Koch's postulates. It analyses their creation in the nineteenth century and their popularity in the twentieth century. As a genre of historiography, references to the postulates are anecdotes. In referring to a historical event that never happened,...

journal_title：Microbes and infection

authors： Gradmann C

更新日期：2014-11-01 00:00:00

abstract：:Parasites of the Leishmania genus are the causative agents of a complex disease called leishmaniasis. Many activities of infected cells including their responses to a range of stimuli are modulated by Leishmania parasites. This review will profile some of the parasite molecules that target host cell processes for whic...

journal_title：Microbes and infection

authors： Kima PE

更新日期：2014-09-01 00:00:00

abstract：:Infection of colonic epithelial cells by Shigella is associated with the type III secretion system, which serves as a molecular syringe to inject effectors into host cells. This system includes an extracellular needle used as a conduit for secreted proteins. Two of these proteins, IpaB and IpaD, dock at the needle tip...

journal_title：Microbes and infection

authors： Meghraoui A,Schiavolin L,Allaoui A

更新日期：2014-07-01 00:00:00

abstract：:The internalization of Aspergillus fumigatus into lung epithelial cells is critical for the infection process in the host. Gliotoxin is the most potent toxin produced by A. fumigatus. However, its role in A. fumigatus internalization into the lung epithelial cells is still largely unknown. In the present study, the de...

journal_title：Microbes and infection

authors： Jia X,Chen F,Pan W,Yu R,Tian S,Han G,Fang H,Wang S,Zhao J,Li X,Zheng D,Tao S,Liao W,Han X,Han L

更新日期：2014-06-01 00:00:00

abstract：:The Escherichia coli NleH1 and NleH2 virulence proteins differentially regulate host transcription of innate immunity genes. The mouse pathogen Citrobacter rodentium encodes one NleH protein, which functions equivalently to E. coli NleH1. We examined the impact of host genetics and intestinal inflammation on the contr...

journal_title：Microbes and infection

authors： Feuerbacher LA,Hardwidge PR

更新日期：2014-05-01 00:00:00

abstract：:Leishmania amazonensis infection promotes alteration of host cellular signaling and intracellular parasite survival, but specific mechanisms are poorly understood. We previously demonstrated that L. amazonensis infection of dendritic cells (DC) activated extracellular signal-regulated kinase (ERK), an MAP-kinase kinas...

journal_title：Microbes and infection

authors： Boggiatto PM,Martinez PA,Pullikuth A,Jones DE,Bellaire B,Catling A,Petersen C

更新日期：2014-04-01 00:00:00

abstract：:Overlapping peptides of different lengths from a certain immunodominant region can be presented by the same HLA class I molecule and elicit different T cell responses. However, how peptide-length specificity of antigen-specific CD8(+) T lymphocytes influence cross-reactivity profiles of these cells remains elusive. Th...

journal_title：Microbes and infection

authors： Motozono C,Yokoyama M,Sato H,Ueno T

更新日期：2014-04-01 00:00:00

abstract：:Macrophages serve as permissive niches for Escherichia coli (E. coli) K1 to attain high grade bacteremia in the pathogenesis of meningitis in neonates. Although pterin levels are a diagnostic marker for immune activation, the role of macrophages in pterin production and in the establishment of meningitis is unknown. H...

journal_title：Microbes and infection

authors： Shanmuganathan MV,Krishnan S,Fu X,Prasadarao NV

更新日期：2014-02-01 00:00:00

abstract：:Despite high vaccination coverage, pertussis remains an important respiratory infectious disease and the least-controlled vaccine-preventable infectious disease in children. Natural infection with Bordetella pertussis is known to induce strong and long-lasting immunity that wanes later than vaccine-mediated immunity. ...

journal_title：Microbes and infection

authors： Lim A,Ng JK,Locht C,Alonso S

更新日期：2014-01-01 00:00:00

abstract：:Infection of mice with Plasmodium berghei NK65 represents a well-recognized malaria model in which infection is accompanied by an intense hepatic inflammatory response. Enzyme-inducible nitric oxide synthase is an important regulator of inflammation and leukocyte recruitment in microvessels, but these functions have y...

journal_title：Microbes and infection

authors： Oliveira-Lima OC,Bernardes D,Xavier Pinto MC,Esteves Arantes RM,Carvalho-Tavares J

更新日期：2013-11-01 00:00:00

abstract：:Most studies of Salmonella enterica serovar Typhimurium infection focus only on the pathogenicity of one strain. We investigated whether differences in pathogenicity of two wild-type S. Typhimurium strains; DT120 and SL1344, were related to gut invasion or the resulting immune response. Oral administration of a ten-fo...

journal_title：Microbes and infection

authors： Brandt R,Petersen A,Brix S,Licht TR,Frøkiær H

更新日期：2013-11-01 00:00:00

abstract：:Host-lipidome caters parasite interaction by acting as first line of recognition, attachment on the cell surface, intracellular trafficking, and survival of the parasite inside the host cell. Here, we summarize how protozoan parasites exploit host-lipidome by suppressing, augmenting, engulfing, remodeling and metaboli...

journal_title：Microbes and infection

authors： Rub A,Arish M,Husain SA,Ahmed N,Akhter Y

更新日期：2013-09-01 00:00:00

abstract：:Host defense requires the maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 and the induction of pyroptotic cell death, which depends on the activation of inflammatory Caspases within inflammasomes by innate immune cells. Several cytosolic pattern recognition receptors (PRRs) have ...

journal_title：Microbes and infection

authors： Radian AD,de Almeida L,Dorfleutner A,Stehlik C

更新日期：2013-07-01 00:00:00

abstract：:The inner ear has been regarded as an immunoprivileged site because of isolation by the blood-labyrinthine barrier. Several reports have indicated the existence of immune cells in the inner ear, but there are no reports showing immunocompetence of the cochlear tissue. In this report, we examined the potential involvem...

journal_title：Microbes and infection

authors： Hayashi Y,Onomoto K,Narita R,Yoneyama M,Kato H,Nakagawa T,Ito J,Taura A,Fujita T

更新日期：2013-07-01 00:00:00

abstract：:Nonsense-mediated mRNA decay (NMD) is an essential and conserved cellular mRNA quality control mechanism. RNA signals to express viral genes from overlapping open reading frames potentially initiate NMD, nevertheless it is not clear whether viral RNAs are sensitive to NMD or if viruses have evolved mechanisms to evade...

journal_title：Microbes and infection

authors： Nakano K,Ando T,Yamagishi M,Yokoyama K,Ishida T,Ohsugi T,Tanaka Y,Brighty DW,Watanabe T

更新日期：2013-06-01 00:00:00

abstract：:Very recently, a new avian flu outbreak in humans, which is caused by a novel H7N9 influenza A virus (AIV), was reported in China. As of April 13, 2013, 49 confirmed cases (mainly middle-aged to elderly males), including 11 deaths, were reported in China. Here we analyzed the genomic signatures and protein sequences o...

journal_title：Microbes and infection

authors： Liu Q,Lu L,Sun Z,Chen GW,Wen Y,Jiang S

更新日期：2013-06-01 00:00:00

abstract：:Erythritol is a four-carbon sugar preferentially utilized by Brucella spp. The presence of erythritol in the placentas of goats, cows, and pigs has been used to explain the localization of Brucella to these sites and the subsequent accumulation of large amounts of bacteria, eventually leading to abortion. Here we show...

journal_title：Microbes and infection

authors： Petersen E,Rajashekara G,Sanakkayala N,Eskra L,Harms J,Splitter G

更新日期：2013-06-01 00:00:00

abstract：:In experimental Trypanosoma cruzi infections, severe thymic atrophy leads to release of activated CD4(+)CD8(+) double-positive (DP) T cells to the periphery. In humans, activated DP T cells are found in the blood in association with severe cardiac forms of human chronic Chagas disease. The mechanisms underlying the pr...

journal_title：Microbes and infection

authors： Nardy AF,Luiz da Silva Filho J,Pérez AR,de Meis J,Farias-de-Oliveira DA,Penha L,de Araújo Oliveira I,Dias WB,Todeschini AR,Freire-de-Lima CG,Bellio M,Caruso-Neves C,Pinheiro AA,Takiya CM,Bottasso O,Savino W,Morrot A

更新日期：2013-05-01 00:00:00

abstract：:Chlamydia pneumoniae is a respiratory pathogen involved in the onset of chronic inflammatory pathologies. Dendritic cells (DC), are major players in spreading of C. pneumoniae from the lungs, a crucial step leading to disseminated infections. Less is known concerning modulation of DC functions consequent to encounter ...

journal_title：Microbes and infection

authors： Flego D,Bianco M,Quattrini A,Mancini F,Carollo M,Schiavoni I,Ciervo A,Ausiello CM,Fedele G

更新日期：2013-02-01 00:00:00

abstract：:Lactic acid bacteria (LAB) show anti-inflammatory effects, and their genomic DNA was identified as one of the anti-inflammatory components. Despite the differences in anti-inflammatory effects between live LAB dependent not only on genus but also species, this effect has not been compared at the genomic DNA level. We ...

journal_title：Microbes and infection

authors： Hiramatsu Y,Satho T,Irie K,Shiimura S,Okuno T,Sharmin T,Uyeda S,Fukumitsu Y,Nakashima Y,Miake F,Kashige N

更新日期：2013-02-01 00:00:00

abstract：:In schistosomiasis, the current control strategy does not prevent reinfection, therefore, vaccine strategies are essential to combat the Schistosoma mansoni. The efficacy vaccine depends on parasite stage and effective adjuvant. We have recently demonstrated that S. mansoni schistosomula tegument (Smteg) is able to ac...

journal_title：Microbes and infection

authors： Teixeira de Melo T,Araujo JM,Campos de Sena I,Carvalho Alves C,Araujo N,Toscano Fonseca C

更新日期：2013-01-01 00:00:00

abstract：:This review considers whether the products of schistosomes in the mammalian host can be considered as virulence factors. These include: the cercarial secretions used in infection, those of the migrating schistosomulum, surface-exposed proteins of adult worms in the portal system and their gut vomitus in the context of...

journal_title：Microbes and infection

authors： Wilson RA

更新日期：2012-12-01 00:00:00

abstract：:Pseudomonas aeruginosa, a significant cause of human morbidity and mortality, uses a type 3 secretion system (T3SS) to inject effector toxins into host cells. We previously reported that P. aeruginosa uses ADP-ribosyltransferase (ADPr) activity of the T3SS effector ExoS for intracellular replication. T3SS translocon (...

journal_title：Microbes and infection

authors： Hritonenko V,Evans DJ,Fleiszig SM

更新日期：2012-12-01 00:00:00

abstract：:Staphylococcus aureus infections are of major importance in human and veterinary medicine. Studies of the virulence of this bacterium are complicated by inconsistent results obtained in different animal models. We searched for an uncomplicated and inexpensive model suitable to study virulence of poultry strains of S. ...

journal_title：Microbes and infection

authors： Polakowska K,Lis MW,Helbin WM,Dubin G,Dubin A,Niedziolka JW,Miedzobrodzki J,Wladyka B

更新日期：2012-11-01 00:00:00